Reinventing Alternative Education: An Assessment of Current State Policy and How to Improve It

This report identifies seven model policy elements that states should incorporate in order to develop and improve alternative pathways for struggling students and former dropouts. Jobs for the Future performed this comprehensive 50-state policy scan to assess the extent to which state policy aligns with these model elements

Six Pillars of Effective Dropout Prevention and Recovery: An Assessment of Current State Policy and How to Improve it

This report identifies six model policy elements that frame a sound legislative strategy for dropout prevention and recovery, and it assesses the extent to which recent state policy aligns with these model elements. Overall, 36 states and the District of Columbia have enacted new dropout legislation since 2002. While some states have moved toward adopting comprehensive dropout prevention and recovery policies, nearly all of them have a long way to go. Nearly one-third of the nation—14 states—have enacted no new laws aimed at increasing graduation rates in the past eight years

Payments for Ecosystem Services: Legal and Institutional Frameworks

Analysis and engagement with partners working on ecosystem services transactions, policies and laws over the past 10 years have demonstrated a clear need to better understand the legal and institutional frameworks that have the potential to promote or hinder the development of payments for ecosystem services (PES) schemes, as well as the complex legal considerations that affect ecosystem services projects. In response, the IUCN Environmental Law Centre and The Katoomba Group have worked on a joint initiative to analyze the legal and institutional frameworks of water-related PES schemes and projects in four Andean countries: South America (Northeastern)-Brazil; Bolivia, Colombia and Peru. It has resulted in this report. Country-based analysts with experience in ecosystem services transactions have developed country and project assessments to define existing and recommend future regulatory and institutional frameworks that enable equitable and long-lasting ecosystem services transactions. Partners from North America (Central America)-Costa Rica; North America-Mexico; Ecuador and the North America-United States provided feedback on the assessments. The country assessments yielded lessons which were used to develop a set of recommendations on legal frameworks, property rights, enabling institutions, PES contracts, and governance issues supporting the future development of PES schemes

Zebrafish Neural Tube Morphogenesis Requires Scribble-Dependent Oriented Cell Divisions

How control of subcellular events in single cells determines morphogenesis on the scale of the tissue is largely unresolved. The stereotyped cross-midline mitoses of progenitors in the zebrafish neural keel [1–4] provide a unique experimental paradigm for defining the role and control of single-cell orientation for tissue-level morphogenesis in vivo. We show here that the coordinated orientation of individual progenitor cell division in the neural keel is the cellular determinant required for morphogenesis into a neural tube epithelium with a single straight lumen. We find that Scribble is required for oriented cell division and that its function in this process is independent of canonical apicobasal and planar polarity pathways. We identify a role for Scribble in controlling clustering of α-catenin foci in dividing progenitors. Loss of either Scrib or N-cadherin results in abnormally oriented mitoses, reduced cross-midline cell divisions, and similar neural tube defects. We propose that Scribble-dependent nascent cell-cell adhesion clusters between neuroepithelial progenitors contribute to define orientation of their cell division. Finally, our data demonstrate that while oriented mitoses of individual cells determine neural tube architecture, the tissue can in turn feed back on its constituent cells to define their polarization and cell division orientation to ensure robust tissue morphogenesis

‘Never testing for HIV’ among Men who have Sex with Men in Viet Nam: results from an internet-based cross-sectional survey

© 2013 García et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Background Men who have sex with men in Viet Nam have been under-studied as a high-risk group for HIV infection, and this population’s percentage and determinants of HIV testing have not been comprehensively investigated. Methods A national Internet-based survey of self-reported sexual and health seeking behaviours was conducted between August and October 2011 with 2077 Vietnamese men who had sex with men in the last twelve months to identify the frequency of ‘never testing for HIV’ among Internet-using MSM living in Viet Nam, as well as the factors associated with this HIV-related high-rish behavior. Logistic regression analyses were conducted to assess the demographic characteristics and behaviours predicting never testing for HIV. Results A total of 76.5% of men who have sex with men who were surveyed reported never having been voluntarily tested for HIV. Predictors of never being tested included having a monthly income less than VND 5 Million, being a student, using the Internet less than 15 hour per week, and not participating in a behavioural HIV intervention. Conclusions Never testing for HIV is common among Internet-using men who have sex with men in Viet Nam. Given the dangerously high prevalence of this high-risk behaviour, our findings underscore the urgent need for segmented and targeted HIV prevention, care and treatment strategies, focusing on drastically reducing the number of men who have sex with men never testing for HIV in Viet Nam

Wnt-Dependent Epithelial Transitions Drive Pharyngeal Pouch Formation

The pharyngeal pouches, which form by budding of the foregut endoderm, are essential for segmentation of the vertebrate face. To date, the cellular mechanism and segmental nature of such budding have remained elusive. Here, we find that Wnt11r and Wnt4a from the head mesoderm and ectoderm, respectively, play distinct roles in the segmental formation of pouches in zebrafish. Time-lapse microscopy, combined with mutant and tissue-specific transgenic experiments, reveal requirements of Wnt signaling in two phases of endodermal epithelial transitions. Initially, Wnt11r and Rac1 destabilize the endodermal epithelium to promote the lateral movement of pouch-forming cells. Next, Wnt4a and Cdc42 signaling induce the rearrangement of maturing pouch cells into bilayers through junctional localization of the Alcama immunoglobulin-domain protein, which functions to restabilize adherens junctions. We propose that this dynamic control of epithelial morphology by Wnt signaling may be a common theme for the budding of organ anlagen from the endoderm

Phytochemical and Biological Profile of Essential Oils of Elionurus muticus (Spreng.) Growing in Northeastern Argentina

The purpose of this study was to investigate essential oils (EOs) from leaves of Elionurus muticus growing in Northeastern Argentina regarding their physicochemical profiles as well as their biological potential. Roots of a selected E. muticus population were investigated too. For this purpose, EOs of fresh materials were obtained by steam distillation and the chemical composition was characterized by gas chromatography GC/MS-FID. Antibacterial, antioxidant and eco-toxicity activities of the essential oils (EOs) were tested by in vitro assays. The EOs showed three E. muticus chemotypes: citral (neral+geranial), acorenone+bisabolone, acorenone+geranial. EO of roots of citral population contains mainly acorenone derivatives. EOs have high antibacterial effect against Staphylococcus aureus, being found minor antibacterial effect against Gram-negative bacteria. The half-maximal inhibitory concentration of EOs against DPPH⋅ were 7.1–30.0 mg/mL and the eco-toxicity was high with LD50 <39 μg/mL. Based on the findings, given the high variability in their chemical composition and biological activity of E. muticus EO and the promising yields, it could be potentially chosen for industrial applications.Fil: Celaya, Liliana Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina. Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales; ArgentinaFil: Le Vraux, María Agostina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina. Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales; ArgentinaFil: Heit, Cecilia Inés. Instituto de Investigaciones y Prestaciones de Servicios. Universidad Nacional de Jujuy;Fil: Viturro, Carmen Ines. Universidad Nacional de Jujuy. Centro Interdisciplinario de Investigaciones en Tecnologías y Desarrollo Social para el Noa. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta-Jujuy. Centro Interdisciplinario de Investigaciones en Tecnologías y Desarrollo Social para el Noa; ArgentinaFil: Martina, Pablo F.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Universidad Nacional de Misiones. Instituto de Biología Subtropical; Argentina. Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales; Argentin

Hiperuricemia y componentes del síndrome metabólico en niños y adolescentes obesos

ResumenIntroducciónLa hiperuricemia se ha observado como una alteración metabólica adicional en pacientes adultos obesos, pero es poco conocida su magnitud en pacientes pediátricos.ObjetivosAnalizar la asociación entre ácido úrico sérico (AUS) con magnitud de la obesidad general y visceral y con otras mediciones bioquímicas en niños y adolescentes obesos de Santiago, Chile.Sujetos y métodoEn un estudio transversal se evaluaron 770 niños (edades: 6-15 años) de un colegio público de Santiago, Chile, encontrando 227 obesos (29%) (IMC>2 DE, estándares OMS). Se seleccionaron aleatoriamente 90 niños y aceptaron participar 77, sin otras enfermedades crónicas. Se evaluó: peso, talla, perímetro abdominal, adiposidad visceral con ultrasonografía abdominal y mediciones metabólicas: insulinemia, glucemia (HOMA), lípidos séricos, aspartato aminotransferasa, alanina aminotransferasa (ALT) y AUS.ResultadosLas concentraciones de AUS fueron 0,200±0,065mmol/l. El AUS fue mayor en niños con valores de hiperinsulinismo (ajustado según edad): 0,221±0,075 vs 0,183±0,054mmol/l (p<0,01), sin diferencias según HOMA; las diferencias también se observaron según ALT (>vs<26 U/ml): 0,238±0,070 vs 0,178±0,054mmol/l, p<0,001; la regresión logística controlando por sexo, edad e intensidad de la obesidad mostró solo las ALT asociadas a aumento de AUS. No hubo asociación de mayor AUS con magnitud de IMC, adiposidad visceral o hígado graso.ConclusionesLos niños y adolescentes obesos de Santiago, Chile, tienen una uricemia mayor en asociación a un aumento de la actividad de la enzima ALT e hiperinsulinismo. Se justifica analizar uricemia en el estudio de niños obesos y en su seguimiento.AbstractIntroductionHyperuricaemia has been suggested as an additional metabolic factor in adult obese patients, but it has not been sufficiently studied in paediatric.ObjectivesTo assess the relationship between serum uric acid levels (SUAL) with the level of general and visceral obesity, and other biochemical parameters in children and adolescents of Santiago, Chile.Subjects and methodA cross sectional study was conducted on 770 children and adolescents (ages: 6-15 y.) from a public school in Santiago, Chile, of whom 227 (29%) were obese (BMI>2 SD, WHO growth standards). Ninety subjects were randomly selected and 77 with no other chronic disease (41 males) accepted to participate. Data was collected on weight, stature, abdominal circumference (AC), visceral adiposity using ultrasound, and other biochemical measurements including fasting glucose, insulin, serum lipids, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and SUAL.ResultsThe mean SUAL was 0.200±0.065mmol/L, and was increased in children with hyperinsulinism (adjusted by age: 0.221±0.075 vs 0.183±0.054mmol/L; P<.01), with no significant differences according to HOMA. Differences were also found between children with ALT>or<26 U/mL: 0.238±0.070 vs 0.178±0.054mmol/L, P<.001. The logistic regression showed the increased SUAL was only associated with increased ALT. No significant differences were found in general or visceral adiposity measurements or fatty liver.ConclusionsChildren and adolescents from Santiago, Chile have higher uric acid serum uric acid levels as well as an association with increased ALT and insulin. It is demonstrated in this study that uric acid should be measured in obese children and adolescents, and in their follow up

”I hvilken grad vil selvledelse bidra for å realisere intensjoner til handlinger?”

På bakgrunn av vår store interesse for tematikken selvledelse og hvordan det kan bli benyttet som hjelpeverktøy for selvutvikling, ønsker vi å finne ut hvorfor noen individer stort sett gjennomfører det de har sagt og planlagt å gjøre, mens noen ikke alltid evner å gjøre tanker til proaktive handlinger. Dette gir utgangspunkt for problemstillingen vår: “I hvilken grad vil selvledelse bidra for å realisere intensjoner til handlinger?”. For å på best mulig måte besvare vårt forskningsspørsmål har vi benyttet oss av metodetriangulering, hovedtyngden ligger i det kvalitative perspektiv. Vi har utvalgte ledere som målgruppe og har fulgt disse gjennom denne forskningsprosessen hvor vi har forsket på deres atferdsmønster og innhentet empiri ut i fra deres eget perspektiv. Videre har vi i etterkant utført dybdeintervjuer for nærmere observasjon og dermed innhentet rikere empiri i en annen kontekst. Til slutt har vi kategorisert empirien systematisk, for å få en indikasjon på hva som må ligge til rette for at informantene vil kunne bevege seg fra tanker og intensjoner til proaktive handlinger. Vi ønsker å belyse og bevisstgjøre tematikken selvledelse for våre informanter da vi mener at det kan være et hjelpeverktøy som vil bidra til å evne gjennomføring hos individet. Basert på våre empiriske funn og gjennom byggeklossene (jf. kategorisering) vi har brukt for å utforme vår teori, har vi konkrete anbefalte strategier til våre informanter, for hvordan de bevisst kan lede seg selv til å evne gjennomføring. Vår konklusjon for å oppnå selvledelse er at prosessen må starte i selvet, og vår forskning viser at det er visse momenter som vi mener ligger bedre til rette enn andre. Følgende momenter er; aktør, rasjonell, bevisst, verdibevisst, høy selvinnsikt og høy gjennomføringsevne. Ved å følge vår teori utarbeidet med bakgrunn for momentene mener vi dette vil gi et godt utgangspunkt for å bevege seg fra en intensjon til en proaktiv handling